Caroline of the Palatinate-Zweibrücken (Henriette Caroline Christiane Louise; 9 March 1721 – 30 March 1774) was Landgravine of Hesse-Darmstadt by marriage to Louis IX, Landgrave of Hesse-Darmstadt.
She was famed as one of the most learned women of her time and known as The Great Landgräfin.