Casimir Pfyffer von Altishofen (10 October 1794, Rome – 11 November 1875) was a Swiss politician and jurist.
He was mayor of Lucerne (1832-1835), President of the Swiss National Council (1854/1855) and five times President of the Federal Supreme Court.
Kasimir-Pfyffer-Strasse in Lucerne is named for him.