Margarethe Siems (20 December 1879 – 13 April 1952) was a German operatic soprano and voice teacher.
A Kammersängerin of the Dresden State Opera, between 1909 and 1912 Siems created leading roles in three operas by Richard Strauss: Chrysothemis in Elektra, the Marschallin in Der Rosenkavalier, and Zerbinetta in Ariadne auf Naxos.