Sophia Fowler Gallaudet (March 20, 1798 – May 13, 1877) was the wife of Thomas Hopkins Gallaudet.
As the founding matron of the school that became Gallaudet University, she played an important role in deaf history, even playing a key role in lobbying US congressmen in the effort to establish Gallaudet (then the "National Deaf-Mute College").
She was appointed to be the first matron of the Columbia Institution on May 30, 1857 and held the position for nine years, until August 1, 1866.