Gabriele Santini (20 January 1886, Perugia - 13 November 1964, Rome) was an Italian conductor, particularly associated with the Italian opera repertory.
He studied in Perugia and Bologna, and made his debut in 1906, as assistant conductor to Gino Marinuzzi and Arturo Toscanini, appearing with them throughout Italy.
He was particularly associated with La Scala in Milan, the San Carlo in Naples, and the Rome Opera, where he was artistic director from 1945 to 1962.
Considered one of great Verdi conductors of his generation, he left notable recordings of Simon Boccanegra and Don Carlos, both with Tito Gobbi and Boris Christoff, as well as La traviata with Maria Callas.