Tokugawa Mitsukuni (?? ??, 11 July 1628 – 14 January 1701) or Mito Komon (????) was a prominent daimyo who was known for his influence in the politics of the early Edo period.
He was the third son of Tokugawa Yorifusa (who in turn was the eleventh son of Tokugawa Ieyasu) and succeeded him, becoming the second daimyo of the Mito Domain.