Isaac Newton Van Nuys (; November 20, 1836 – February 12, 1912) was an American businessman, farmer and rancher who owned the entire southern portion of the San Fernando Valley—an area 15 miles long and 6 miles wide.
With the approach of the Owens River aqueduct, and the possibility of intensive small farming, Los Angeles speculators, including Harry Chandler of the Los Angeles Times, combined to buy out Van Nuys in 1909 and develop the San Fernando Valley.
Issac Van Nuys was not the founder of Van Nuys in 1911—he died in 1912—but was made the honorary godfather of the hardscrabble town, later to be the Valley's center, by the development syndicate as a promise in the land sale.
Still, as a pioneer resident and honorary godfather of Van Nuys, there are schools, streets, libraries, and a Liberty Ship with the name of Van Nuys.