She studied at the University of Tel Aviv, initially in the Faculty of Humanities, and later at the Rubin Academy of Music, graduating in 1976.
She married Jacob Zakai and they had two daughters.She appeared with Yehudi Menuhin in a concert at Castel Gandolfo for Pope John Paul II, having previously appeared at Menuhin's festival as a soloist in Bach's Mass in B minor.
Her 1982 recording of Mahler's Symphony No.
2 with Georg Solti won the Grammy for Best Overall Classical Recording at the 1982 awards.Zakai later moved into teaching, becoming a professor at the Buchmann-Mehta School of Music, University of Tel Aviv.