Tan Sri Mohd Isa bin Abdul Samad (Jawi: ???? ???? ?? ????????; born 14 November 1949) is a Malaysian politician.
He is the former Menteri Besar of Negeri Sembilan for 22 years from April 1982 to March 2004 and a former Minister of Federal Territories (2004–2005).
Isa was a member and former vice-president of United Malays National Organisation (UMNO), a component of the Barisan Nasional (BN) coalition until 2018 when he quit to become an Independent.
He was also the former chairman of Federal Land Development Authority (FELDA) and Land Public Transport Commission (SPAD).