Domingo de Caycedo y Sanz de SantamarÃa (August 4, 1783 – July 1, 1843) was a Colombian statesman who served as Vice-president of Gran Colombia and the Republic of New Granada, and due to the absence of the presidents, he himself served as President a total of eleven times, making him the person to have served more times as President of Colombia.
He is also credited for creating the Republic of New Granada after the division of Venezuela and Ecuador.