Nicola Mancino (born 15 October 1931 in Montefalcione) is an Italian politician.
He was President of the Italian Senate from 1996 to 2001.
He was also president of Campania's regional parliament from 1965 to 1971, governor of Campania from 1971 to 1972 and Minister of the Interior from 1992 to 1994.