Francis Wayles Eppes VII (September 20, 1801 – May 10, 1881) was a planter from Virginia who became prominent near and in Tallahassee, Florida.
His maternal grandparents were President Thomas Jefferson and his wife Martha; his paternal grandparents were Francis Wayles Eppes VI, also a prominent planter in Virginia, and his wife Elizabeth Wayles, half-sister to Martha Wayles Skelton Jefferson.
After marrying and moving in 1829 from Virginia with his family to near Tallahassee, Florida, Eppes established a cotton plantation.
His first wife died and in 1837 he married a second time.
With both wives, he had a total of 13 children.
Long interested in education, in 1856 Eppes donated land and money to designate a school in Tallahassee as one of the first two state-supported seminaries, now known as Florida State University.
He served as president of its board of trustees for eight years.