Issam Jad'aan Zahreddine (Arabic: ???? ????? ??? ??????) (September 1961 – 18 October 2017), also transliterated as Issam Zaher Eldin or Issam Zaher al-Deen, was a Major General of the Syrian Republican Guard who played a major role in the Syrian Civil War, leading Syrian government forces on several fronts.
His most prominent role was the leadership of the surrounded Syrian forces during the over three-year long Siege of Deir ez-Zor.
On 18 October 2017, Zahreddine was killed by a land mine explosion during operations against the Islamic State of Iraq and the Levant on Saqr island in Deir ez-Zor.