Mariano de Aycinena y Piñol (1789-1855) was wealthy and influential Guatemalan merchant family and an important conservative politician.
A younger son of the first marquis of Aycinena, peninsular-born Juan Fermín de Aycinena (1729-1796), Mariano was a leader of Guatemalan independence from Spain.
He served governor of the State of Guatemala in the Central American Federation from 1 March 1827 to 12 April 1829 and patriarch of the Aycinena family.
The family had the commercial monopoly in Central American during the Spanish colonial era later year thanks to the Consulado de Comercio.
He was one of the signatories of Central American independence and lobbied heavily for the annexation of Central America to the Mexican Empire of Agustín de Iturbide.
This arrangement would keep the family's economic position and privileges following independence.
After being expelled along with the Aycinena family in 1829 after being defeated by Francisco Morazán, went into exile in the United States and then to Mexico.
He came back to Guatemala after the conservatives had allied with general Rafael Carrera; but then he retired from public life and hand the Aycinena family leadership to Juan José de Aycinena y Piñol.