Vincenzo Negrini (born Vincenzo Bartolomeo Trentanove) (24 August 1804 – 16 August 1840) was an Italian bass-baritone opera singer.
Born in Cesena, he sang leading bass and baritone roles in Italy's major opera houses and created several roles in early 19th-century operas, most notably Oroveso in Bellini's Norma and Folco in Donizetti's Ugo, conte di Parigi.
Severe heart disease caused him to retire from the stage in June 1840.
He died in Milan two months later at the age of 35.