Manuel Antonio de Varona y Loredo (November 25, 1908 in Camagüey, Cuba – October 29, 1992 in Miami, Florida, United States) was a Cuban lawyer and politician.
Varona is 7th Prime Minister of Cuba in 1948-1950, and served as president of the Cuban Senate from 1950 to 1952.
In 1960 Varona went into exile after denouncing Castro's communist regime.
He was a member of the exile coalition Cuban Revolutionary Council (1961-1964).