Middleton (February 15, 1895 – March 18, 1978) was a physician and cardiologist in Indianapolis, Indiana, who is best known for his efforts to open opportunities for black physicians to serve on the staffs of Indianapolis hospitals and for his community service.
Middleton was born in Denmark, South Carolina, and received a bachelor of arts degree from Benedict College (1919) in Columbia, South Carolina.
He attended two years of medical school at Boston University before transferring to Meharry Medical College, in Nashville, Tennessee, where he received a medical degree (M.D.) in 1926.
Middleton took short courses for additional training at Harvard University; the University of London, England; the University of Michigan; Indiana University; and Michael Reese Hospital in Chicago.
In 1928 Middleton moved to Anderson, Indiana, where he joined the staff of Saint Johns Hospital.
Around 1935 he relocated to Indianapolis, established a private medical practice, and volunteered at Indianapolis General (City) Hospital's outpatient heart clinic.
Middleton was accepted as a member of City Hospital staff in 1942 and joined the staffs at other Indianapolis hospitals.
Middleton wrote several articles relating to cardiology that appear in state and national medical journals.
He was a member of the American Medical Association, the National Medical Association, the American Heart Association, the Indiana State Medical Association, the Hoosier State Medical Society, and others.
Middleton, a member of the National Association for the Advancement of Colored People, was actively involved in Indianapolis philanthropic and social organizations, most notably in leadership roles in the Young Men's Christian Association.
He was particularly active in Indianapolis's Senate Avenue YMCA and its successor, the Fall Creek Parkway YMCA.
Middleton served on state-level YMCA committees and was a member of the YMCA's national council and a delegate to the International YMCA Conference (1955).
He co-chaired the United Negro College Fund's Indiana fundraising campaign (1950–51) and was a board member of the Indianapolis Community Chest.
Middleton was active in the Zeta Phi chapter of the Omega Psi Phi fraternity and a member of Indianapolis's Mount Paran Baptist Church.
He is buried in Crown Hill Cemetery, Indianapolis, Indiana.