Henning Brandis (born 17 July 1916 in Elberfeld, died 16 November 2004 in Bonn) was a German physician and microbiologist.
He was Professor of Medical Microbiology and Immunology and Director of the Institute for Medical Microbiology and Immunology at the University of Bonn from 1967 until his 1984 retirement.
He was editor-in-chief of the journal Zeitschrift für Immunitätsforschung (now Immunobiology).
He was a member of the Academy of Sciences Leopoldina and received the Officer's Cross of the Order of Merit of the Federal Republic of Germany in 1976 for services to medical microbiology.