Giovanni Battista Rinuccini (15 September 1592 – 28 December 1653) was an Italian Roman Catholic archbishop in the mid-seventeenth century.
He was a noted legal scholar and became chamberlain to Pope Gregory XV.
He was made the Archbishop of Fermo in Italy by Pope Urban VIII in 1625.
He is best known for his time as Papal Nuncio to Ireland during the Irish Confederate Wars (1645–49) during the Wars of the Three Kingdoms.
Rinuccini became the dominant figure of the Clerical Faction of the Confederate leadership, pushing for greater concessions to the Catholic Church in any treaty of alliance with Irish Royalists.