Isaac Sterling "Ike" Struble (November 3, 1843 – February 13, 1913) was a four-term Republican Representative of Iowa's 11th congressional district.
Serving from 1883 to 1891, the Plymouth County resident was a noted congressional opponent of plural marriage in the Utah Territory.
The member of a politically active family, Isaac's six brothers included John T.
Struble of Iowa, and George R.
Struble, former speaker of the Iowa House of Representatives.