She is the Chancellor of Edith Cowan University since April 2019.Sanderson attended Churchlands Senior High School and the University of Western Australia.
She entered the public service after graduation, serving in senior positions in the Treasury and Transport Departments of the Government of Western Australia.
Sanderson was chief executive officer of Fremantle Ports from 1991 to 2008.
In the position, she undertook a restructuring of the operations of Fremantle Harbour, and was credited with increasing the port's efficiency and returning it to profit.
After leaving Fremantle Ports, Sanderson was named Agent-General for Western Australia for a three-year term (from 2008 to 2011), representing the government in the United Kingdom and Europe.
On her return to Australia, she entered the private sector, holding board-level positions with several publicly traded companies.
She was appointed to succeed Malcolm McCusker as Governor of Western Australia in August 2014.