Edwin Santibáñez (born 1 February 1980 in Torreón) is a retired Mexican footballer.
He played for Club León of the Liga de Ascenso.
In the Mexican draft of July 5, he decided to end his career as a player.
He is currently an assistant coach for Gustavo Matosas at Club America.
Santibáñez played for Mexico at the 1997 FIFA U-17 World Championship in Egypt.