Mark Brian Wise (born November 9, 1953 in Montreal, Quebec) is a Canadian-American theoretical physicist.
He has conducted research in elementary particle physics and cosmology.
He is best known for his role in the development of heavy quark effective theory (HQET), a mathematical formalism that has allowed physicists to make predictions about otherwise intractable problems in the theory of the strong nuclear interactions.
He has also published work on mathematical models for finance and risk assessment.