It was one of the first publications dedicated to the history of psychiatry, and was a rational discourse that dealt with topics such as demonology, lycanthropy, religious obsession and other abnormal thought processes.
The book covered psychiatric issues from the 15th to the 19th century, and is still read today.
Another important work by Calmeil was an 1826 treatise that discussed general paresis, considered to be the first separately identifiable neuropsychiatric disease entity.
General paresis was originally described a few years earlier by Antoine Laurent Bayle (1799–1858).
Calmeil is credited with introducing the concept of "epileptic absence" for the brief loss of consciousness or confusion observed in epileptic patients.