Margaret Ekpo (July 27, 1914 – September 21, 2006) was a Nigerian women's rights activist and social mobilizer who was a pioneering female politician in the country's First Republic and a leading member of a class of traditional Nigerian women activists, many of whom rallied women beyond notions of ethnic solidarity.
She played major roles as a grassroot and nationalist politician in the Eastern Nigerian city of Aba, in the era of an hierarchical and male-dominated movement towards independence, with her rise not the least helped by the socialization of women's role into that of helpmates or appendages to the careers of males.