Michele Pennisi (born 23 November 1946) is an Italian Archbishop of the Roman Catholic Church in Sicily, and a noted opponent of the Sicilian Mafia.
He has served as Archbishop of Monreale since 8 February 2013.
Following reorganisation of the Sicilian church in 2000, Archbishops of Monreale are no longer Metropolitans, but they retain the personal rank of Archbishop.