Ephraim Kibbey (1754 or 1756 – 1809) was a United States soldier in the American Revolution, a frontiersman and early settler of Ohio, the leader of Mad Anthony Wayne's famous forty scouts in the Northwest Indian War, and a member of the 1st Ohio General Assembly.
He was a contemporary of Daniel Boone, Simon Kenton, and Simon Girty, and what Daniel Boone was for Kentucky, Kibbey and his fellow pioneer, Benjamin Stites, were to early southwest Ohio.