Ghulam Mustafa Jatoi (Sindhi:???? ????? ?????) (Urdu: ???? ????? ??????) (14 August 1931 – 20 November 2009) was a Pakistani politician, and was Prime Minister of Pakistan in an acting capacity for three months, from 6 August 1990 to 6 November 1990.
Ghulam Mustafa Jatoi's ancestors were Murids of the Pir's of Sarhandi.