Isabel Zendal Gómez (born 1773) was a Spanish nurse from Galicia who took part in the Balmis Expedition (1803-1806, Real Expedición Filantrópica de la Vacuna), which took smallpox vaccination to South America.She had previously been the supervisor or "rectoress" of an orphanage in A Coruña, and her role on the expedition was to take care of the group of 22, later 26, small orphan boys who carried the virus from which the vaccine was prepared.The three-year expedition aimed to vaccinate millions of people against smallpox, and had the support of king Charles IV of Spain whose daughter had died of the disease.