MarÃa Manuela Dominga de Espejo y Aldaz, known as Manuela de la Santa Cruz y Espejo (around these times it was common to have 4,5 or more names) (Spanish: Manuela de la Santa Cruz y Espejo; 20 December 1753 – 1829) was an Ecuadorian journalist, nurse, feminist, and revolutionary.
She was the sister of Eugenio Espejo, with whom she discussed and shared Enlightenment and revolutionary, pro-revolutionary thought and ideas.