George Frederick Sprague (September 3, 1902 – November 24, 1998) was an American geneticist and maize researcher.
He was a faculty member at the Iowa State University and the University of Illinois and a researcher at the U.S.
Department of Agriculture.
He is credited with developing a genetically strong line of maize known as Iowa Stiff Stalk Synthetic.
A recipient of the Wolf Prize in Agriculture, Sprague was also a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences.