Samuel Seymour Epstein (April 13, 1926 – March 18, 2018) was a physician and, at the time of his death, professor emeritus of environmental and occupational health at the School of Public Health of the University of Illinois at Chicago.
He is known for his contributions on avoidable causes of cancer, for which he was given the Right Livelihood Award in 1998.
His papers are held at the National Library of Medicine in Bethesda, Maryland.