José Cardoso Cassandra (born 17 February 1964 in Príncipe) is a São Toméan politician.
He has been President of the Regional Government of Príncipe since 5 October 2006.
Cassandra is leader of the Union for Change and Progress in Príncipe (UMPP), a regionalist independent group supported by the ruling Force for Change Democratic Movement-Democratic Convergence Party (MDFM-PCD) coalition.
He was reelected in August 2010.