Seargent Smith Prentiss (30 September 1808 in Portland, Maine – 1 July 1850 in Natchez, Mississippi) was an attorney and politician.
He served as a state representative in Mississippi and then was elected in 1836 as US representative from the state in the Twenty-fifth United States Congress, serving one term from 1837 to 1839.
Prentiss was noted as one of the most remarkable orators of his day.
Daniel Webster, known himself as a top flight orator, said that he had never heard a speaker as powerful as Prentiss.