Catherine Michelle of Spain (Spanish: Catalina Micaela de Austria; 10 October 1567 – 6 November 1597) was a Duchess consort of Savoy who served as Regent of Savoy several times during the absence of her spouse, Charles Emmanuel I, Duke of Savoy.
As the youngest surviving daughter of Philip II of Spain and Elisabeth of Valois, she was the sister of Isabella Clara Eugenia, Governor of the Habsburg Netherlands.