Isabella of Savoy (11 March 1591 – 28 August 1626) was a daughter of Charles Emmanuel I, Duke of Savoy, and Catherine Michelle of Spain.
Her maternal grandparents were Philip II of Spain and Elisabeth of Valois, her paternal grandparents were Emmanuel Philibert, Duke of Savoy and Margaret of France, Duchess of Berry.
She was the Hereditary Princess of Modena, dying before her husband succeeded to the Duchy of Modena in 1628.