He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology.
In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment.
Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment.
He has worked in a variety of areas including biochemistry, immunology, and cancer genetics.
His groundbreaking work on the T-cell receptor has been postulated to be in consideration for a Nobel Prize.