Isabella, Princess of Asturias (Spanish: María Isabel Francisca de Asís Cristina Francisca de Paula Dominga; 20 December 1851 – 22 April 1931), was the eldest daughter of Queen Isabella II and her husband Francis, Duke of Cádiz, twice recognized as the heir presumptive to the Spanish throne and given the title Princess of Asturias, which was reserved for the heir to the Spanish crown.
She was married to Prince Gaetan, Count of Girgenti (a son of King Ferdinand II of the Two Sicilies), who committed suicide just three years after their marriage on 13 May 1868.
Infanta Isabella was a prominent figure at the royal court of Spain during the reign of her brother King Alfonso XII of Spain and during the minority of her nephew King Alfonso XIII.
She was the most popular member of the Spanish royal family for most of her life.
After the fall of the monarchy of Alfonso XIII, she refused the offer of officials of the Second Spanish Republic to continue to reside in Spain.
She died in a matter of days after taking up a new life in exile in France.