Margaret of Guelders (11 August 1436, Grave, North Brabant – 2 November 1486, Simmern) was a noblewoman from what is now the Netherlands.
She was the daughter of Arnold of Egmond, Duke of Guelders, and Catherine of Cleves (1417–1479).
Via her mother she was a granddaughter of Adolph I, Duke of Cleves.
In Lobith on 6 August 1454 she married Frederick I, Count Palatine of Simmern - they had ten children:
Katherine (1455 – 28 December 1522)
Stephen (25 February 1457 – 1488/9)
William (2 January 1458 – 1458)
John I (15 May 1459 – 27 January 1509)
Frederick (10 April 1460 – 22 November 1518)
Rupert (16 October 1461 – 19 April 1507)
Anne (30 July 1465 – 15 July 1517)
Margaret (2 December 1466 – August 1506)
Helene (1467 – 21 February 1555)
William (20 April 1468 – 1481)