She is best known for her portrayal of Mega Mindy, the singing superhero of the eponymous television series (2006–present).
She firmly established herself as an accomplished singer during the 2007 series of Flemish TV programme Steracteur Sterartiest, the Flemish version of Soapstar Superstar, which she won.In 2008, her television successes were recognised when she received the Rising Star Award from the Flemish Television Academy.
In February 2010, Souffriau gave her first solo concert in a tribute performance to Belgian songstress Ann Christy, widely acclaimed as one of Flanders' greatest musical talents.