Irene Fenwick (September 5, 1887 – December 24, 1936) was an American stage and silent film actress.
She was married to Lionel Barrymore from 1924 until her death in 1936.
Fenwick has several surviving features, mainly because she worked for Edison-Kleine, an affiliate of the Edison Company, which has numerous surviving shorts, which is fortunate considering the vintage of these films.
Years before marrying Lionel, Irene had dated Lionel's brother, John.