Guillermo Enio Burdisso (born 26 September 1988) is an Argentine football defender who plays for Club Atlético San Lorenzo.
Guillermo is the younger brother of former defender Nicolás Burdisso.
He has spent his entire career playing in Argentina, apart from a loan spell at his brother's club in the 2010–11 season.
Burdisso won his first and, as of October 2014, only international cap for Argentina in 2010 in which he also scored.