Blondel completed major commissions for the Palace of Fontainebleau, the Palace of Versailles, the Louvre Museum, the Brongniart Palace (also known as the Bourse de Paris), the Luxembourg Palace, and the churches of St.Thomas Aquinas and Notre-Dame-de-Lorette.
Blondel's 1814 painting La Circassienne au Bain became infamous during the early part of the 20th century for being the subject of the largest claim for financial compensation made against the White Star Line, for a single item of luggage lost by a passenger on the RMS Titanic.