Ignacia de Loyola de Palacio y del Valle Lersundi (16 September 1950 – 13 December 2006) was a Spanish politician.
She was among the first women to rise to political prominence in Spain during the early years of reconstituted democracy.
She was a minister in the Spanish government from 1996 to 1998 (Ministry of Agriculture, Fisheries and Food), and a member of the European Commission from 1999 to 2004.