Sophia Eleonore of Saxony (23 November 1609 – 2 June 1671) was a duchess of Saxony by birth and the landgravine of Hesse-Darmstadt from 1627 to 1661 through her marriage to Landgrave George II.
She was the eldest surviving child of John George I, Elector of Saxony, and Magdalene Sibylle of Prussia.