André Kana-Biyik (born 1 September 1965) is a former Cameroonian footballer who played as a defender.
The brother of François, he started a professional career in 1986 with Diamant Yaoundé.
From 1988 to 1994 he played in France Ligue 1 with FC Metz and Le Havre AC, making 93 appearances and scored 8 goals.
With the Cameroon national football team he participated at the 1990 and 1994 FIFA World Cups.
Kana-Biyik was sent off in Cameroon's opening game of the 1990 World Cup, a game against Argentina that Cameroon won 1–0.
His brother, François Omam-Biyik, scored the goal that defeated the South Americans.
His son Jean-Armel Kana-Biyik, is also a professional footballer.