Nicole-Reine Lepaute (née Étable de la Briere; also known as Hartense Lepaute or Hortense Lepaute), (5 January 1723 – 6 December 1788) was a French astronomer and mathematician.
Lepaute predicted the return of Halley's Comet by calculating the timing of a solar eclipse and constructing a group of catalogs for the stars.
The asteroid 7720 Lepaute is named in her honour, as is the lunar crater Lepaute.
She was also a member of the Scientific Academy of Béziers.