Jorge de Lencastre (English: George; 21 August 1481 – 22 July 1550) was a Portuguese prince, illegitimate son of King John II of Portugal and Ana de Mendonça, a maid of Joanna la Beltraneja.
He was created the second Duke of Coimbra in 1509.
He was also master of the Order of Santiago and administrator of the Order of Aviz from 1492 to 1550.