George II of Hesse-Darmstadt, German: Georg II von Hessen-Darmstadt (Darmstadt, 17 March 1605 – 11 June 1661) was the Landgrave of Hesse-Darmstadt from 1626 to 1661.
He was the son of Ludwig V and Magdalene of Brandenburg.
He married Sophia Eleonore of Saxony on 1 April 1627.
From 1645 to 1648 he led the so-called Hessenkrieg against the Landgravine Amalie Elizabeth of Hesse-Kassel over the inheritance of the extinct line of Hesse-Marburg.
This conflict resulted in the loss of Hesse-Marburg to Hesse-Kassel.