Sai Jayalakshmy Jayaram (born 16 February 1977 in Chennai) is a former professional female tennis player.
In her career, she won four singles and 25 doubles titles on the ITF circuit.
On 25 December 2000, she reached her best singles ranking of world number 331.
On 18 June 2001, she peaked at number 249 in the WTA doubles rankings.
Playing for India at the Fed Cup, Jayalakshmy Jayaram has a win–loss record of 6–7.
She made her WTA Tour main-draw debut at the 2003 Hyderabad Open, in the doubles event partnering Rushmi Chakravarthi.
Sai Jayalakshmy Jayaram retired from professional tennis 2010.